Post-transcriptional control of mRNAs by RNA-binding proteins (RBPs) plays a prominent role in the regulation of gene expression. RBPs interact with mRNAs to control their biogenesis, splicing, localization, translation and stability. Defects in this regulation process can lead to a wide range of human diseases from neurological disorders to cancer.
In my research I am dissecting the role of RBPs associated with programmed cell death (apoptosis) in the germ line of C. elegans. To reveal insights I am using PAR-CLIP and further biochemical assay to understand the system how RBPs orchestrate post-transcriptional gene expression.