Diana Doda

Diana Doda

Ph.D. Student



Curriculum vitae

The focus of my research is to study the function of Cullin-4 RING ligase (CRL-4) complexes in regulating proliferation of mammalian cells. CRL-4 use a class of WD-40 repeat-containing proteins, named as DCAFs (DDB1 and Cullin-4 associated factors) which function as substrate adaptors. Using RNAi-based screens, we have identified specific DCAFs, which may be required for faithful S-phase progression and/or DNA repair pathways. My PhD project aims at elucidating the function and regulation of these DCAFs, with a particular emphasis to identify their physiological substrates relevant to maintain genome stability.